UP-Pharma is a privately held company applying scientific knowledge and technology to solutions in life science. Since 2006, UP-Pharma has applied immunoanalytical expertise and mass spectrometry in support of new drug development for the pharmaceutical and biopharmaceutical industries. This specialization has resulted in the emergence of UP-Pharma as a leading bioanalytical CRO. We offer rapid method development of PK/PD assays to support clinical and pre-clinical studies while adhering to GLP regulations. UP-Pharma Biomarker and Immunoanalytical Division provides method development, validation, and sample analysis for novel and esoteric biomarkers as well as the analysis of biotherapeutics and antibodies.
UP-Pharma discovery team specializes in rapid development, abbreviated validations, and high-throughput analysis of non-GLP samples.
Structure Analysis of Protein and Peptide
A series of services, including the analysis of purity, structure, physicochemical property of protein and peptide were implemented by using HPLC, electrophoresis and mass spectrometry. Additionally, in order to help the pharmaceutical corporations to finish the registration of the novel protein or peptide drugs successfully, we promise to compose related documents based on our experiment data.
Drug screening
In vitro and in vivo pharmacological tests, synthesis or extraction and purification, and characterization of lead compounds are compared to known drugs.
Preclinical evaluation of new drugs
- General (safety) pharmacology
- Single-dose toxicity
- Multi-dose toxicity
- Teratogenesis
- Vascular irritation
- Hemolysis
- Allergic reaction
- Immunological toxicity, et al.
Immunology Services
- Assay development, optimization, and validation
- Method transfer and verification
- Sample analysis and management
- ELISA, EIA, FIA, LIA
- Immunogenicity testing
- Enzymatic activity assay
Radioisotope Labeling and Detection
- Radioisotope labeling protein, peptides, nucleic acid, small molecular compounds
- Various isotope labeling, including 125I, 131I, 35S, 32P, 99Tc, 3H, 14C
- From trace dose to therapeutic dose
- A variety of radiation detection (α, β, γ)
- PE wizard 1470 γ-counter/Microbeta trilux/Oxidizer 307
- Large-scale frozen sectioner/MD phosphorImager SI/in vivo imaging system